Table 4.
SEC analysis of AD brains.
| Case # | High mwt | Intermediate mwt | ~7 kDa Aβ species | True Monomer | Column |
|---|---|---|---|---|---|
| AD1 | − | + M +D | + | − | S75 |
| AD2 | + M +D | − | − | + | S75 |
| AD3 | + M +D | + M +D | + | + | S75 |
| AD4 | − | + D | + | + | S75 |
| AD5 | + D | + D | + | − | S75 |
| AD6 | + D | + D | − | + | S75 |
| AD7 | − | + M +D | + | + | S75 |
| AD8 | − | + M +D | − | − | S75 |
| AD9 | + M +D | + M +D | − | − | S75 |
| AD10 | − | + M +D | − | − | S75 |
| AD11 | − | + M +D | − | − | S75 |
| AD12 | − | + M +D | − | − | S75 |
| AD13 | − | + M +D | − | − | S75 |
| AD14 | − | + M +D | − | − | S75 |
| AD15 | − | + M +D | − | − | S75 |
| AD16 | − | + M +D | − | − | S75 |
| AD17 | − | + M +D | − | − | S75 |
| AD18 | + M +D | + D | + | + | S75 |
| AD19 | − | + M +D | − | − | S75 |
| AD20 | − | + D | + | + | S75 |
| AD21 | + M +D | + M +D | − | − | S75 |
| AD22 | − | + M +D | − | − | S75 |
| AD23 | − | + M +D | − | − | S75 |
| AD24 | − | + M +D | − | − | S75 |
| AD25 | + M +D | − | − | − | S75 |
| AD26 | + D | + M +D | + | − | S75/S200 |
| AD27 | + M +D | + D | + | + | S75/S200 |
| AD28 | + D | + D | + | + | S75/S200 |
| AD29 | − | + M +D | − | − | S75 |
| AD30 | +M | +M +D | − | −* | S75 |
| AD31 | − | + M +D | − | − | S75 |
| AD32 | − | + M +D | − | − | S75 |
| AD33 | − | + M +D | − | + * | S75 |
The presence or absence of a species is indicated by + or −, respectively. M and D refers to the migration of Aβ on SDS-PAGE, were M=monomer, D=dimer. +* = a very weak signal by WB, but readily detected by ELISA, and −* not detectable by WB, but detectable by ELISA.