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. Author manuscript; available in PMC: 2016 Oct 15.
Published in final edited form as: J Immunol. 2015 Sep 9;195(8):3838–3848. doi: 10.4049/jimmunol.1500203

Figure 8. iNKT cell hypo-responsiveness does not require DCs.

Figure 8

(A, B) CD11c-DOG mice were depleted <95% of CD4+ and CD8+ CD11c+ DCs in the spleen as described. C57BL/6 (B6) or DC-depleted CD11c-DOG (DOG) mice were either left untreated or injected i.v. with 4μg of αGalCer (αGC). One month later mice were injected i.v. with 1μg αGalCer, and 90 min later splenic iNKT cells were analyzed for the expression of surface markers (A) and of intracellular cytokines (B). Statistically significant differences (Anova) of B6(control vs αGC) versus the DC-depleted DOG(control vs αGC) groups are indicated. ns = not significant. Representative data from one of three independent experiments are shown.