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. Author manuscript; available in PMC: 2016 Oct 15.
Published in final edited form as: J Immunol. 2015 Sep 14;195(8):3978–3991. doi: 10.4049/jimmunol.1500963

Figure 6. Adoptive cell transfer of fibrocytes augments Wilms’ tumor 1 (WT1)-regulated gene expression during TGFα induced fibrosis.

Figure 6

CCSP/− and CCSP/TGFα mice were placed on doxycycline (Dox)-treated food for 14 days and fibrocytes (0.7×106 cells/mice) or saline was infused intravenously via the tail vein. After fibrocyte infusion, mice were continued on Dox for another 7 days and lungs were harvested to quantify WT1-regulated network of genes by RT-PCR. The transcripts of WT1-regulated network genes (A) MYCN, (B) IL-10, (C) Col1α, (D) THBS4, and (E) TERT are shown as the fold induced obtained by normalizing the gene expression to a hypoxanthine guanine phosphoribosyl transferase (HPRT) control. Data shown are mean + SEM values (n=4–6/group). Statistical significance between groups was measured using One-way ANOVA with Sidak’s multiple comparison test. *P<0.05, **P<0.005, ***P<0.0005, ****P<0.0001.