Skip to main content
. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Phytochemistry. 2015 Aug 28;118:102–108. doi: 10.1016/j.phytochem.2015.08.010

Table 3.

Cytotoxicity data for cytochalasins C (12), D (13) and Q (14).a

Compound Tumor Cell Lineb
PC-3M NCI-H460 SF-268 MCF-7 MDA-MB-231
12 1.65 ± 0.33 1.06 ± 0.03 0.96 ± 0.08 > 5 1.72 ± 0.27
13 1.03 ± 0.08 0.22 ± 0.02 0.43 ± 0.06 1.44 ± 0.26 1.01 ± 0.08
14 1.53 ± 0.12 1.51 ± 0.16 1.31 ± 0.08 > 5 1.32 ± 0.13
doxorubicin 0.25 ± 0.02 0.05 ± 0.01 0.45 ± 0.07 0.32 ± 0.09 0.67 ± 0.11
a

Results are expressed as IC50 value ± standard deviation in μM. Doxorubicin and DMSO were used as positive and negative controls.

b

Cell lines used: PC-3M = metastatic human prostate adenocarcinoma; NCI-H460 = human non-small cell lung cancer; SF-268 = human CNS glioma; MCF-7 = human breast adenocarcinoma; MDA-MB-231 = metastatic human breast adenocarcinoma.