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. Author manuscript; available in PMC: 2016 Oct 15.
Published in final edited form as: J Immunol. 2015 Sep 11;195(8):3705–3715. doi: 10.4049/jimmunol.1500780

Figure 4.

Figure 4

Sfpi1lck−/− mice have enhanced germinal center B-cell development after MOG35-55 immunization. WT and Sfpi1lck−/− mice were immunized with MOG35-55 and analyzed 12, 25, and 28 days after immunization. A, Splenocytes were stained with germinal center B-cell markers and analyzed flow cytometry. B, Percent of GC B-cells and number of GC B-cells in wild type and Sfpi1lck−/− mice are indicated. C-D, Serum IgG, IgG2c, and IgG1 titers were measured on days 12 (C) and 25 (D). Data are representative of 2-3 experiments with 3-6 mice per group (A-C). Statistical significance was determined with a two-tailed t test, *, p<0.05; **, p<0.005.