Changes in BMI and lipid parameters on pegvisomant (PEG). Left panels: changes in BMI on pegvisomant. Individual values are given as a function of BMI at diagnosis: BMI<25 kg/m2 (A), 25≤BMI<30 kg/m2 (B), 30≤BMI<35 kg/m2 (C), BMI≥35 kg/m2 (D). Right-hand panels: changes in plasma lipid levels on pegvisomant. Individual values of total cholesterol (TC, E), triglycerides (TG, F), HDL cholesterol (HDLc, G) and LDL cholesterol (LDLc, H) are shown. *P<0.05.