Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 5;5:14700. doi: 10.1038/srep14700

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Com-mons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Enhancing PIP₂ in the inner membrane leaflet leads to a fortification of the membrane-cytoskeleton shell mediated through ezrin. A redistribution of the actin cytoskeleton occurs in response to an increased PIP₂ level (a). Ezrin depletion via ezrin siRNA, neomycin microinjection or ezrin inhibitor NSC 668394, however, results in more condensed, flattened cells (c).