Table 3. NsSNP distributions of the transmembrane domain of wolframin from the TMHMM server.
| Distribution of Transmembrane Domain | Range of Amino Acid | Number of Reported Pathogenic nsSNPs | Number of Predicted Pathogenic nsSNPs | Total Number of nsSNPs in Each Domain | Ratio of Each Domain (%) |
|---|---|---|---|---|---|
| Outside | 1–310 | 4 | 0 | 4 | 5.714 |
| TMhelix 1 | 311–333 | 1 | 1 | 2 | 2.857 |
| Inside | 334–339 | 0 | 0 | 0 | 0 |
| TMhelix 2 | 340–362 | 0 | 1 | 1 | 1.429 |
| Outside | 363–404 | 2 | 3 | 5 | 7.142 |
| TMhelix 3 | 405–422 | 0 | 0 | 0 | 0 |
| Inside | 423–428 | 1 | 0 | 1 | 1.429 |
| TMhelix 4 | 429–451 | 3 | 1 | 4 | 5.714 |
| Outside | 452–492 | 0 | 0 | 0 | 0 |
| TMhelix 5 | 493–515 | 3 | 0 | 3 | 4.286 |
| Inside | 516–526 | 0 | 1 | 1 | 1.429 |
| TMhelix 6 | 527–549 | 4 | 0 | 4 | 5.714 |
| Outside | 550–558 | 2 | 0 | 2 | 2.857 |
| TMhelix 7 | 559–581 | 0 | 0 | 0 | 0 |
| Inside | 582–587 | 0 | 0 | 0 | 0 |
| TMhelix 8 | 588–610 | 1 | 2 | 3 | 4.286 |
| Outside | 611–629 | 0 | 0 | 0 | 0 |
| TMhelix 9 | 630–652 | 1 | 0 | 1 | 1.429 |
| Inside* | 653–890 | 28 | 11 | 39 | 55.714 |
| Total | 890-amino acids | 50 | 20 | 70 | 100 |
*The domain highlighted in bold is the distribution of the C terminal domain.