Table 4. The prediction results to the transmembrane domain of wolframin from the TMHMM server and UniProt database.

TMHMM server		UniProt database
Distribution of Transmembrane Domain	Range of Amino Acid	Distribution of Transmembrane Domain	Range of Amino Acid
Outside	1–310	Outside	1–313
TMhelix-1	311–333	TMhelix-1	314–334
Inside	334–339	Inside	335–339
TMhelix-2	340–362	TMhelix-2	340–360
Outside	363–404	Outside	361–401
TMhelix-3	405–422	TMhelix-3	402–422
Inside	423–428	Inside	423–426
TMhelix-4	429–451	TMhelix-4	427–447
Outside	452–492	Outside	448–464
TMhelix-5	493–515	TMhelix-5	465–485
		Inside	486–495
		TMhelix-6	496–516
Inside	516–526	Outside	517–528
TMhelix-6	527–549	TMhelix-7	529–549
Outside	550–558	Inside	550–562
TMhelix-7	559–581	TMhelix-8	563–583
Inside	582–587	Outside	584–588
TMhelix-8	588–610	TMhelix-9	589–609
Outside	611–629	Inside	610–631
TMhelix-9	630–652	TMhelix-10	632–652
Inside*	653–890	Topological domain	653–869
		TMhelix-11	870–890
Total	890-amino acids	Total	890-amino acids

^*The domains highlighted in bold are the distributions of the C terminal domain.