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. 2015 Oct 5;5:14733. doi: 10.1038/srep14733

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(A) Molecular model of donor ubiquitin (Ub1, blue) bound to the catalytic pocket of HECT domain of SMURF2. (B) Inset of A showing the details of the hydrogen-bond interaction between SMURF2 C-Lobe (yellow) and catalytically bound Ub1 (blue). Thioester bond between Gly76 and Cys716 is denoted. Unbound Lys 734 is also shown. (C) Molecular model of ubiquitin (green, Ub2) bound to Lys734 site with donor ubiquitin (Ub1) bound to the catalytic pocket. The displacement of Ub1 (shown in blue and orange) due to the presence of Ub2 is indicated by an arrow. (D) Inset of C showing the hydrogen-bond interactions between SMURF2 C-Lobe (yellow) and Ub1 (blue) in the presence of Lys734 bound Ub2 (green). The isopeptide bond between Lys734 and Gly76 of Ub2 is also shown.