Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram illustrating the feedback loop of FGF/FGFR signaling and brachyury. FGF binds to FGFR to induce FGFR phosphorylation and further activate MEK/ERK, which results in an increased brachyury expression. Brachyury in turn promotes the secretion of FGF and enhances FGF/FGFR signaling and, subsequently, MEK and ERK. This feedback loop of FGF/FGFR signaling and brachyury may be critical for chordoma cell growth, survival and EMT.
