Table 2.
Mixed-effects model of ADAS-Cog rate of change
| Term | Value | Standard error | t-value | P value |
|---|---|---|---|---|
| Baseline rate | 1.519 | 0.238 | 6.371 | <.001 |
| Baseline curvature | 0.094 | 0.028 | 3.340 | .001 |
| Female effect | 1.179 | 0.311 | 3.793 | <.001 |
| APOE ε4+ effect | 1.284 | 0.311 | 4.131 | <.001 |
| APOE ε4++ effect | 2.305 | 0.482 | 4.787 | <.001 |
| Education effect | 0.107 | 0.048 | 2.231 | .026 |
| Baseline cognition effect | −0.436 | 0.082 | −5.303 | <.001 |
| Age effect | −0.013 | 0.020 | −0.640 | .523 |
| Female effect on curvature | 0.090 | 0.040 | 2.275 | .023 |
| APOE ε4+ effect on curvature | 0.134 | 0.039 | 3.414 | .001 |
| APOE ε4++ effect on curvature | 0.276 | 0.059 | 4.646 | <.001 |
Abbreviation: ADAS-Cog, Alzheimer's disease assessment scale-cognitive subscale; APOE, apolipoprotein E.
NOTE. Values are coefficients in model 2. To avoid confusion, only the effects on rate of change, i.e. interactions with time are displayed here. Units are ADAS-Cog score change per year. Women had greater rates of decline than men. Positive changes in ADAS-Cog scores indicate worsening. Bold P values are statistically significant.