Skip to main content
. 2015 Jul 21;1(2):103–110. doi: 10.1016/j.trci.2015.07.001

Table 2.

Mixed-effects model of ADAS-Cog rate of change

Term Value Standard error t-value P value
Baseline rate 1.519 0.238 6.371 <.001
Baseline curvature 0.094 0.028 3.340 .001
Female effect 1.179 0.311 3.793 <.001
APOE ε4+ effect 1.284 0.311 4.131 <.001
APOE ε4++ effect 2.305 0.482 4.787 <.001
Education effect 0.107 0.048 2.231 .026
Baseline cognition effect −0.436 0.082 −5.303 <.001
Age effect −0.013 0.020 −0.640 .523
Female effect on curvature 0.090 0.040 2.275 .023
APOE ε4+ effect on curvature 0.134 0.039 3.414 .001
APOE ε4++ effect on curvature 0.276 0.059 4.646 <.001

Abbreviation: ADAS-Cog, Alzheimer's disease assessment scale-cognitive subscale; APOE, apolipoprotein E.

NOTE. Values are coefficients in model 2. To avoid confusion, only the effects on rate of change, i.e. interactions with time are displayed here. Units are ADAS-Cog score change per year. Women had greater rates of decline than men. Positive changes in ADAS-Cog scores indicate worsening. Bold P values are statistically significant.