Table 4.

Mixed-effects model of CDR-SB rate of change over time

Term	Value	Standard error	t-value	P value
Baseline rate	0.595	0.085	7.003	<.001
Baseline curvature	0.023	0.008	2.850	.004
Female effect	0.325	0.111	2.934	.003
APOE ε4+ effect	0.496	0.111	4.461	<.001
APOE ε4++ effect	0.837	0.171	4.895	<.001
Education effect	0.008	0.008	1.018	.309
Baseline cognition effect	0.023	0.017	1.341	.180
Age effect	0.010	0.007	1.331	.183
Female effect on curvature	0.033	0.011	2.914	.004
APOE ε4+ effect on curvature	0.017	0.011	1.486	.138
APOE ε4++ effect on curvature	0.078	0.017	4.559	<.001

Abbreviation: CDR-SB, clinical dementia rating sum of boxes; APOE, apolipoprotein E.

NOTE. Values are coefficients in model 2. For brevity, only the effects on rate of change, i.e. interactions with time are displayed here. Units are CDR-SB score units change per year. Women had greater rates of decline than men. Bold P values are statistically significant.