Fig. 3.

HPB enhances paclitaxel and SAHA induced transformed cell death but not normal cell death. Cell growth and viability of (A) HFS and (B) LNCaP cells cultured with HPB with 5 nM paclitaxel or 5 µM SAHA alone and in combination with HPB for 72 h. Cell growth and viability were determined as previously described. Data are represented as mean ± SD (P < 0.001). The P value was derived from the two-way ANOVA. (C) HFS and (D) LNCaP cell lysates prepared at 24 and 48 h after treatment for immunoblot analysis of γH2AX and acetylated histone H3 (Acet-H3). Total H3 is a loading control.