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Expression of the BCR is necessary for B-cell proliferation. BCRpos and BCRneg B cells were generated by TAT-Cre transduction of B cells from B1-8f/+, bcl-2tg mice. After 3 d in culture, cells were either (A) labeled with CFSE and stimulated for 3–4 d (data are representative of five biological replicates) or (B) stimulated for 24 h with the indicated mitogen and analyzed by FACS (data are representative of two biological replicates). Live cells were gated as ToPro3−, CD19+.
