Figure 1. Global gene expression profiling of VAT and SAT before and after extensive weight loss.

(A) VAT and SAT samples were obtained from individuals who underwent two-step bariatric surgery and microarray data were generated. (B) Gene expression data for different adipose tissue depots was analyzed independently by comparing to the gene expression data of lean individuals. Differentially expressed probe sets, protein coding genes as well as the metabolic genes in iAdipocytes1850 were identified. (C) The overlap between the differentially expressed metabolic genes in iAdipocytes1850 in two different adipose tissue depots were shown and used in network dependent analysis.