Table 3.

Biospecimens and Data Collected from Large-Scale Prevention Trials

	PCPT	SELECT	BCPT	STAR
BASELINE SAMPLES (PRE-THERAPY)
Serum	X		X	X
Plasma		X
White Blood Cells	X	X	X	X
Red Blood Cells		X
Toenail Clippings		X
SERIAL SAMPLE COLLECTIONS DURING TRIAL (DURING AND POST-THERAPY)
Blood (as above)	Annual	Year 5 (all) 6 months, Year 1, 2, 4, 6, 8 (subset)
TUMOR TISSUE COLLECTED
Invasive Target Cancers	X	X	X	X
All Other Invasive Cancers			X	X
DATA COLLECTION
Sociodemographic	X	X	X	X
Family Cancer History	Prostate	Prostate, lung, colon	Breast	Breast
Medical History, including height, weight, cardiovascular health, prior cancers.	X Plus detailed anthropomorphic data	X	X Plus hysterectomy and menopausal status	X Plus hysterectomy status
Medications	Limited	Extensive	Limited	Limited
Diet	At year 1	At baseline	At baseline and updated
Supplement Use	X	X	Calcium supplements only	Calcium supplements only
Smoking	Baseline only	Baseline and updated	Baseline and updated	Baseline only
Quality of Life	X	On subset only	On subset only	On subset only
OTHER PROCEDURES
Screening Procedures	Annual PSA and DRE	Prostate screening per local site guidelines	Annual Mammography Endometrial biopsy on subset	Annual Mammography