Table 1.
Group | Study Number | Days of vehicle administration | Route | Radiation dose (Gy) | Expected LDXX/30 | Actual LDXX/30 | Number of mice |
---|---|---|---|---|---|---|---|
Admn 1 | 1 | none | none | 8.53 | LD50/30 | LD52/30 | 15 |
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2 | none | none | 8.53 | LD50/30 | LD68/30 | 44 | |
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3 | none | none | 8.53 | LD50/30 | LD40/30 | 38 | |
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4 | none | none | 8.53 | LD50/30 | LD67/30 | 103 | |
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5 | none | none | 8.53 | LD50/30 | LD39/30 | 74 | |
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Admn 2 | 6 | 1 | SQ | 8.53 | LD50/30 | LD35/30 | 20 |
8.72 | LD70/30 | LD55/30 | 20 | ||||
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7 | 1, 3, & 5 | SQ | 8.53 | LD50/30 | LD55/30 | 20 | |
8.72 | LD70/30 | LD75/30 | 20 | ||||
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8 | 1 & 5 | IM | 8.53 | LD50/30 | LD47/30 | 17 | |
8.72 | LD70/30 | LD67/30 | 18 | ||||
9.04 | LD90/30 | LD78/30 | 18 | ||||
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9 | 1 | SQ | 8.53 | LD50/30 | LD40/30 | 20 | |
8.72 | LD70/30 | LD90/30 | 20 | ||||
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10 | 1 | SQ | 8.53 | LD50/30 | LD95/30 | 20 | |
8.72 | LD70/30 | LD55/30 | 20 | ||||
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11 | 2 | SQ | 8.53 | LD50/30 | LD70/30 | 20 | |
8.72 | LD70/30 | LD90/30 | 20 | ||||
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12 | 1 & 2 | SQ | 8.53 | LD50/30 | LD59/30 | 17 | |
8.72 | LD70/30 | LD71/30 | 17 | ||||
9.04 | LD90/30 | LD88/30 | 17 | ||||
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13 | 1 | SQ | 8.72 | LD70/30 | LD65/30 | 20 | |
9.27 | LD96/30 | LD95/30 | 20 | ||||
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14 | 1 | SQ | 9.27 | LD96/30 | LD90/30 | 20 | |
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15 | 3 | SQ | 8.53 | LD50/30 | LD45/30 | 20 | |
8.72 | LD70/30 | LD75/30 | 20 | ||||
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16 | 1, 2, & 3 | SQ | 8.53 | LD50/30 | LD40/30 | 20 | |
8.72 | LD70/30 | LD60/30 | 20 | ||||
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Admn 3 | 17 | 1, 3, 5, 7, 9, & 11 | gavage | 8.53 | LD50/30 | LD63/30 | 40 |
8.72 | LD70/30 | LD90/30 | 39 | ||||
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18 | Daily on days 1 thru 29 | SQ | 8.53 | LD50/30 | LD95/30 | 20 | |
8.72 | LD70/30 | LD100/30 | 20 | ||||
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19 | 1, 3, 5, 7, 9, & 11 | gavage | 8.34 | LD30/30 | LD30/30 | 20 | |
8.53 | LD50/30 | LD65/30 | 20 | ||||
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20 | 1, 3, 5, 7, 9, 11, 13, 15, & 17 | gavage | 8.34 | LD30/30 | LD35/30 | 20 | |
8.53 | LD50/30 | LD70/30 | 20 |