Figure 5.b.

Longitudinal CT analysis of a NHP exposed to 10.74 Gy WTLI, at baseline and followed every 30 days through to early euthanasia on day 101 due to study criteria.

Transverse images were obtained at Apex, Mid and Base of lungs (Figure 4). Total Lung Volume (TLV) is outlined in light blue, pleural effusion (PE) in green, pericardial effusion (PCE) in red and pneumonitis/fibrosis (PF) in pink. The blue bars represent two courses of Dexamethasone administered DPI 79-91 and 93-101 as per study protocol. Pleural Effusion was observed 30-90 DPI. Pericardial Effusion was observed on day 60 at 13.08mL.