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editorial

. 2015 Sep 14;34:44. doi: 10.1186/s40880-015-0049-z

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© Liu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — A summary of the therapeutic role of microRNA-506 (miR-506). miR-506, located on Xq27.3, is down-regulated by methylation. miR-506 directly targets RAD51, cyclin-dependent kinase 4/6-Forkhead box protein M-1 (CDK4/6-FOXM1), and snail family zinc finger 2 (SNAI2), thus repressing homologous recombination (HR), promoting cellular senescence, and suppressing epithelial-mesenchymal transition (EMT), respectively. As a result, miR-506 sensitizes cancer cells to chemotherapy and inhibits cell proliferation and EMT-mediated metastasis