Table 2.
Univariate analysis of potential risk factors for HBV reactivation in HBsAg-negative DLBCL patients
| Factor | Without HBV reactivation [cases (%)] | With HBV reactivation [cases (%)] | P value |
|---|---|---|---|
| Total | 159 | 6 | |
| HBcAb | 0.001 | ||
| – | 110 (69.2) | 0 (0) | |
| + | 49 (30.8) | 6 (100.0) | |
| Age (years) | 0.237 | ||
| ≤60 | 65 (40.9) | 4 (66.7) | |
| >60 | 94 (59.1) | 2 (33.3) | |
| Sex | 1.000 | ||
| Female | 66 (41.5) | 2 (33.3) | |
| Male | 93 (58.5) | 4 (66.7) | |
| ECOG PS | 1.000 | ||
| 0–1 | 137 (86.2) | 5 (83.3) | |
| ≥2 | 22 (13.8) | 1 (16.7) | |
| Bulky mass | 0.343 | ||
| Yes | 115 (72.3) | 6 (100.0) | |
| No | 44 (27.7) | 0 (0) | |
| B symptoms | 1.000 | ||
| – | 118 (74.2) | 5 (83.3) | |
| + | 41 (25.8) | 1 (16.7) | |
| Ann Arbor stage† | 0.211 | ||
| I–II | 79 (49.7) | 1 (16.7) | |
| III-IV | 79 (49.7) | 5 (83.3) | |
| Liver involvement | 1.000 | ||
| – | 151 (95.0) | 6 (100.0) | |
| + | 8 (5.0) | 0 (0) | |
| Spleen involvement | 0.441 | ||
| – | 145 (91.2) | 5 (83.3) | |
| + | 14 (8.8) | 1 (16.7) | |
| Involved extranodal sites | 0.627 | ||
| <2 | 122 (76.7) | 4 (66.7) | |
| ≥2 | 37 (23.3) | 2 (33.3) | |
| Bone marrow involvement | 1.000 | ||
| – | 148 (93.1) | 6 (100.0) | |
| + | 11 (6.9) | 0 (0) | |
| IPI score† | 0.402 | ||
| 0–1 | 68 (42.8) | 1 (16.7) | |
| 2–5 | 90 (56.6) | 5 (83.3) | |
| HBeAb | 0.094 | ||
| – | 146 (91.8) | 4 (66.7) | |
| + | 13 (8.2) | 2 (33.3) | |
| ALT | 0.597 | ||
| ≤40 U/L | 136 (85.5) | 6 (100.0) | |
| >40 U/L | 23 (14.5) | 0 (0) | |
| AST | 0.526 | ||
| ≤45 U/L | 141 (88.7) | 5 (83.3) | |
| >45 U/L | 18 (11.3) | 1 (16.7) | |
| TB | 0.463 | ||
| ≤20.5 μmol/L | 144 (90.6) | 5 (83.3) | |
| >20.5 μmol/L | 15 (9.4) | 1 (16.7) | |
| LDH | 0.681 | ||
| ≤245 U/mL | 97 (61.0) | 3 (50.0) | |
| >245 U/mL | 62 (39.0) | 3 (50.0) |
HBV, hepatitis B virus. Other footnotes as in Table 1.