Table 3.
Overall survival (OS) according to the locations, number of locations, and number of lesions in each location
| Category and variable | Number of patientsa | Median OS (months) | 3-year OS rate (%) | P value |
|---|---|---|---|---|
| Isolated metastasis versus multiple metastases | ||||
| Number of metastatic locations | 0.001 | |||
| Multiple locations | 199 | 22.4 | 24.0 | |
| Isolated location | 306 | 27.4 | 41.6 | |
| Number of metastatic lesions in each location | <0.001 | |||
| Multiple lesions | 410 | 22.8 | 29.5 | |
| Isolated lesion | 95 | 41.0 | 57.6 | |
| Involved locations | ||||
| Bone involvement | 0.404 | |||
| Yes | 333 | 26.2 | 35.8 | |
| No | 172 | 23.9 | 33.5 | |
| Lung involvement | 0.559 | |||
| Yes | 136 | 25.1 | 30.3 | |
| No | 369 | 24.6 | 36.6 | |
| Liver involvement | <0.001 | |||
| Yes | 155 | 19.7 | 21.7 | |
| No | 350 | 28.4 | 41.1 | |
| Distant LN involvement | 0.104 | |||
| Yes | 144 | 23.2 | 27.6 | |
| No | 361 | 26.7 | 37.6 | |
| Number of lesions and locations | ||||
| Isolated bone metastasis | 0.065 | |||
| Single lesion | 50 | 44.2 | 60.7 | |
| Multiple lesions | 133 | 25.0 | 38.6 | |
| Isolated lung metastasis | 0.115 | |||
| Single lesion | 20 | 57.0 | 62.1 | |
| Multiple lesions | 36 | 27.2 | 30.9 | |
| Isolated liver metastasis | 0.473 | |||
| Single lesion | 21 | 25.6 | 43.6 | |
| Multiple lesions | 35 | 17.8 | 22.4 | |
| Isolated distant LN metastasis | – | |||
| Single lesion | 4 | 63.7 | 75.0 | |
| Multiple lesions | 6 | 21.0 | 54.5 | |
| Total isolated metastasisb | 0.002 | |||
| Single lesion | 95 | 41.0 | 57.6 | |
| Multiple lesions | 210 | 23.3 | 34.6 | |
LN lymph node.
aThe total number of patients does not coincide exactly with the corresponding number in Table 2 because the number of lesions for some patients is not specified.
bThese include isolated metastasis in the bones, the lungs, the liver, and distant lymph node.