. 2015 Mar 5;34:6. doi: 10.1186/s40880-015-0002-1

Table 2.

Current status of clinical trials of CIK cells

Target disease	Registered trial	Phase	Combined treatment	Enrolled patients (cases)
Lung cancer	NCT01498055	II/III	None	120
Lung cancer	NCT01631357	II/III	Chemotherapy	200
Small cell lung cancer	NCT01592422	II	Best supportive care	60
Small cell lung cancer	NCT01481259	II/III	Chemotherapy	120
Non-small cell lung cancer	NCT01902875	Undefined	Chemotherapy	100
Non-small cell lung cancer	NCT01871480	II	Gefitinib	50
Hepatocellular carcinoma	NCT01821482	II	DC	100
	NCT01758679	IV	Chemotherapy	120
	NCT01749865	III	None	200
	NCT00769106	III	None	200
Renal cell carcinoma	NCT01924156	I/II	Adenovirus-transfected autologous DC	30
	NCT00862303	I/II	DC + cytokines	100
	NCT01240005	I/II	None	30
Nasopharyngeal carcinoma	NCT01655628	II	Chemotherapy	40
Nasopharyngeal carcinoma	NCT01821495	II	DC	100
Esophageal carcinoma	NCT01691625	Undefined	Chemoradiotherapy + DC	50
Esophageal carcinoma	NCT01691664	Undefined	Radiotherapy + DC	40
Colorectal cancer	NCT01839539	II	DC	60
	NCT02202928	II	Chemoradiotherapy + DC	60
	NCT01929499	II	None	210
Gastric cancer	NCT02215837	II	DC	40
Gastric cancer	NCT01783951	I/II	Chemotherapy + DC	70
Pancreatic cancer	NCT01781520	I/II	Chemotherapy + DC	30
Cholangiocarcinoma	NCT01868490	I/II	None	13
High-risk soft tissue sarcoma	NCT01898663	I/II	Adenovirus-transfected autologous DC	30
Malignant glioma	NCT01235845	I/II	DC	30
Triple negative breast neoplasms	NCT01395056	Undefined	Chemotherapy + DC	50
Solid tumor	NCT01914263	I	None	40
Solid tumor and B-cell lymphoma	NCT01799083	I/II	Chemotherapy	100
Hematologic malignancies	NCT00460694	I/II	None	20
	NCT00477035	I/II	Chemotherapy	22
	NCT01186809	II	None	39
	NCT00186342	Undefined	Ablative allo-HCT	120
Multiple myeloma	NCT00185757	I	None	20
Acute leukemia	NCT01956630	I/II	Genetically modified DC	25
Chronic myeloid leukemia	NCT00815321	II	None	11
Acute myeloid leukemia and myelodysplastic syndrome	NCT00394381	I/II	None	17
Myelodysplastic syndrome	NCT01392989	II	Chemotherapy	21
Lymphoma	NCT01828008	Undefined	None	20
Malignant tumor	NCT01884168	Undefined	DC	30

These data were searched on 15 July 2014 from the website ClinicalTrials.gov (http://www.clinicaltrials.gov). The key word “cytokine-induced killer cells” was used. DC, dendritic cells; HCT, hematopoietic cell transplantation.