Table 4.

The relationship between clinical characteristics and overall survival in HCC patients based on the stratification with the TNM staging system: Cox’s regression analysis

Variable		TNM early stage ( n  = 71)						TNM advanced stage ( n  = 153)
		Univariate analysis		Multivariate analysis				Univariate analysis		Multivariate analysis
		P value		Hazard ratio	95% CI	P value		P value		Hazard ratio	95% CI	P value
Age		0.821		1.001	0.978–1.025	0.920		0.075		0.975	0.956–0.995	0.016
Sex		0.158		3.946	1.332–11.690	0.013		0.372		1.891	0.641–5.577	0.248
HBV DNA (log 10 IU/mL)		0.408		–	–	–		0.328		–	–	–
ALT		0.445		–	–	–		0.994		–	–	–
Cycles of TACE		0.885		–	–	–		0.070		1.305	0.836–2.037	0.242
AST		0.016		1.004	0.996–1.012	0.363		0.001		1.002	0.999–1.005	0.201
ALB		0.149		–	–	–		0.066		0.945	0.893–1.000	0.051
TBIL		0.711		–	–	–		0.024		1.008	0.982–1.035	0.555
AFP		0.022		2.087	0.920–4.736	0.078		0.067		1.144	0.741–1.767	0.545
APTT		0.709		–	–	–		0.068		0.988	0.942–1.037	0.633
Antiviral treatment		0.012		0.372	0.183–0.756	0.006		0.219		–	–	–
Local ablation		0.005		0.280	0.136–0.577	0.001		<0.001		0.211	0.095–0.472	<0.001
Resection		0.023		0.152	0.049–0.473	0.001		0.008		0.308	0.118–0.801	0.016
HBeAg		0.958		–	–	–		0.621		–	–	–
PT		0.241		–	–	–		0.765		–	–	–
Sorafenib therapy		0.943		–	–	–		0.782		–	–	–
Chemotherapeutic agents (epirubicin only: >2 agents)		0.211		–	–	–		0.073		0.881	0.540–1.439	0.613

Abbreviations as in Table 1.