Table 1.

The studies included in this systematic review for the association between Toll-like receptor 3 (TLR3) single nucleotide polymorphisms (SNPs) and the risk of developing cancer

Publication year	Study	Country	Sample size		Source of controls	Genotyping method	Matched factors	Adjusted factors
			Cases	Controls
2007	He et al. [4]	China	434	512	Population-based	Sequencing	Sex and age matched	None
2009	Etokebe et al. [8]	Croatia	130	101	Population-based	qPCR	All females, age not matched	None
2010	Lei et al. [15]	China	981	1221	Population-based	SNP Stream	All females, age matched	Age and BMI
2011	Pandey et al. [7]	India	200	200	Not mentioned, only healthy controls	PCR-RFLP	All females, age matched	Age
	Gast et al. [16]	Germany	763	736	Hospital-based	Two multiplex PCR	Sex not mentioned, age not matched	None
2012	Mandal et al. [6]	India	195	250	Hospital-based	PCR-RFLP	All males, age matched
	Slattery et al.[17]	USA	2309	2915	Population-based	Multiplexed bead array	Sex and age matched	None
2013	Singh et al. [5]	India	200	200	Hospital-based	PCR-RFLP	Sex and age matched	Age, sex, and smoking
	Li et al. [9]	China	466	482	Population-based	PCR-RFLP	Sex and age matched	Sex and age
	Resler et al. [18]	USA	840	800	Population-based	Chip	All females, age matched	Age
	Zeljic et al. [19]	Yugoslavia	93	104	Not mentioned, only healthy controls	qPCR	Sex and age matched	Sex, age, smoking, and alcohol consumption
	Yeyeodu et al. [20]	USA	102	72	Hospital-based	SNP Stream	All females, age not mentioned	None
	Moumad et al. [21]	Germany	472	362	Hospital-based	KASPar	Sex and age matched	Sex and age
2014	Zidi et al. [22]	Tunisia	130	200	Hospital-based	PCR-RFLP	All females, age not matched	None

qPCR, quantitative polymerase chain reaction; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; KASPar, KASPar SNP genotyping system; BMI, body mass index.