. 2015 Jun 10;34:19. doi: 10.1186/s40880-015-0020-z

Table 5.

Pooled ORs and 95 % CIs of TLR3 polymorphisms in the stratified analysis

Stratification	Number of studies	M1			M2			M3			M4			Number of studies	M5
Stratification	Number of studies	OR (95 % CI)	P	I ² (%)	OR (95 % CI)	P	I ²(%)	OR (95 % CI)	P	I ²(%)	OR (95 % CI)	P	I ²(%)		OR (95 % CI)	P	I ²(%)
rs3775290 (C13766T, C > T)
Ethnicity
Asian	3	1.28	0.036	0	1.79	0.032	0	1.33	0.013	0	1.61	0.08	0	4	1.14	0.25^a	58.2
		(1.02-1.62)			(1.05-3.05)			(1.06-1.67)			(0.95-2.71)				(0.91-1.43)
Caucasian	2	0.72	0.372	75.5	1.00	0.996	0	0.76	0.45^a	75.6	1.35	0.52	0	2	0.89	0.60^a	63.6
		(0.34-1.49)			(0.55-1.82)			(0.38-1.54)			(0.54-3.36)				(0.58-1.38)
Cancer type
Genital system neoplasms	4	0.97	0.892	75	1.26	0.3	0	1.04	0.73^a	73.9	1.33	0.2	0		1.07	0.64^a	58.8
		(0.62-1.53)			(0.81-1.95)			(0.84-1.29)			(0.87-2.03)				(0.82-1.39)
Source of controls
Hospital-based		NA			NA			NA			NA			5	1.12	0.32^a	54.7
															(0.90-1.40)
Population-based		NA			NA			NA			NA			1	0.88	0.23
															(0.70-1.09)
rs3775291 (G13909A, L412F, G > A)
Cancer type
Digestive tract cancer	3	1.16	0.132^a	65.4	1.28	0.429	89.1	1.18	0.186	80.4	1.18	0.559^a	87.4	3	1.14	0.288^a	87.5
		(0.96-1.41)			(0.69-2.38)			(0.92-1.51)			(0.68-2.05)				(0.90-1.44)
Breast cancer	2	1.11	0.118	0	1.04	0.739	0	1.10	0.148	0	0.99	0.911	0	2	1.05	0.288	0
		(0.97-1.27)			(0.70-1.55)			(0.97-1.25)			(0.79-1.23)				(0.96-1.16)
Nasopharyngeal carcinoma	1	1.54	0.005		0.81	0.593		1.45	0.012		0.70	0.37		2	1.16	0.083	0
		(1.14-2.09)			(0.37-1.76)			(1.09-1.94)			(0.33-1.52)				(0.98-1.37)
Ethnicity
Caucasian	5	1.02	0.613	0	0.98	0.78	4.6	1.02	0.732	0	0.97	0.685	40.9	5	1.00	0.94	0
		(0.94-1.12)			(0.84-1.14)			(0.93-1.11)			(0.84-1.13)				(0.93-1.07)
Asian	2	1.27	0.048 ^a	54	1.76	0.272	91.2	1.33	0.105	80.7	1.55	0.334	89.5	3	1.21	0.108^a	79.5
		(1.00-1.60)			(0.64-4.82)			(0.94-1.89)			(0.64-3.77)				(0.96-1.53)
African	1	1.23	0.005		0.81	0.593		1.45	0.012		0.70	0.37		1	1.27	0.062
		(1.06-1.43)			(0.37-1.76)			(1.09-1.94)			(0.33-1.52)				(0.99-1.63)
Source of controls
Hospital-based	2	1.50	<0.001	0	1.61	0.466^a	86.8	1.54	<0.001	0	1.37	0.616^a	86.3	2	1.43	<0.001	32.6
		(1.23-1.83)			(0.45-5.84)			(1.27-1.87)			(0.40-4.76)				(1.23-1.67)
Population-based	6	1.05	0.259	0	1.00	0.999	0	1.04	0.338	0	0.98	0.748	26.9	7	1.02	0.465^a	0
		(0.97-1.14)			(0.87-1.15)			(0.96-1.12)			(0.86-1.12)				(0.97-1.08)
Sample size
Large	5	1.05	0.218	0	0.98	0.823	0	1.04	0.328	0	0.96	0.545	0	5	1.02	0.629	0
		(0.97-1.14)			(0.86-1.13)			(0.96-1.12)			(0.84-1.10)				(0.96-1.08)
Small	3	1.41	<0.001	45.6	1.76	0.184^a	73.7	1.47	<0.001	21.1	1.63	0.242^a	73.9	4	1.30	<0.001	47.9
		(1.16-1.70)			(0.77-4.05)			(1.23-1.76)			(0.72-3.65)				(1.15-1.47)
rs3775292 (intron 3, C > G)
Cancer type
Colorectal cancer	2	0.93	0.609^a	82.2	0.89	0.657^a	68	0.93	0.464^a	63.8	0.92	0.797^a	78.2	2	0.94	0.233	0
		(0.69-1.25)			(0.54-1.48)			(0.76-1.13)			(0.50-1.69)				(0.86-1.04)
Breast Cancer	1	1.06	0.601		1.14	0.607		1.07	0.535		1.12	0.656		1	1.06	0.499
		(0.86-1.30)			(0.69-1.90)			(0.87-1.30)			(0.68-1.86)				(0.90-1.26)
Skin malignant melanoma	1	0.91	0.411		1.09	0.753		0.93	0.503		1.12	0.659		1	0.96	0.683
		(0.73-1.14)			(0.64-1.84)			(0.75-1.15)			(0.67-1.89)				(0.80-1.16)
rs5743312 (C9948T, intron 3, C > T)
Ethnicity
Asian		NA			NA			NA			NA			2	1.17	0.017	25.3
															(1.03-1.33)
Caucasian		NA			NA			NA			NA			2	0.99	0.995	0
															(0.83-1.21)
Sample size
Large	2	1.02	0.82	0	1.89	<0.001	4	1.08	0.268	37.2	1.87	0.001	0	2	1.11	0.305^a	61.7
		(0.88-1.17)			(1.32-2.70)			(0.94-1.24)			(1.31-2.65)				(0.99-1.24)
Small	1	0.99	0.97		1.70	0.569		1.04	0.9		1.70	0.566		2	1.02	0.894	0
		(0.51-1.93)			(0.28-10.45)			(0.55-1.98)			(0.28-10.40)				(0.78-1.32)

NA, not available. Other footnotes as in Table 4. The bold means the significant results.