Table 5.

Univariate and Multivariate Cox regression analysis of potential prognostic factors for 464 lung cancer patients

Variable	Univariate model			Multivariate model
	HR	95% CI	P	HR	95% CI	P
Age				–	–	–
<60 years	1.000
≥60 years	1.151	0.926–1.432	0.206
Sex				–	–	–
Female	1.000
Male	1.285	0.997–1.657	0.053
Smoking status
No	1.000			1.000
Yes	1.533	1.224–1.919	<0.001	1.462	1.080–1.980	0.014
Treatment
Multimodality therapy without operation	1.000			1.000
Operation alone	0.231	0.173–0.309	<0.001	0.568	0.367–0.880	0.011
Operation and multimodality therapy	0.326	0.250–0.425	<0.001	0.492	0.362–0.669	<0.001
T stage
T1	1.000			1.000
T2	1.176	0.820–1.686	0.378	1.081	0.753–1.552	0.671
T3	2.019	1.382–2.951	<0.001	1.352	0.920–1.987	0.124
T4	2.162	1.436–3.253	<0.001	1.013	0.668–1.536	0.951
N stage
N0	1.000			1.000
N1	1.043	0.730–1.489	0.817	0.789	0.549–1.133	0.199
N2	1.756	1.346–2.293	<0.001	0.797	0.599–1.058	0.117
N3	2.725	1.958–3.793	<0.001	1.155	0.816–1.636	0.416
M stage
M0	1.000			1.000
M1	3.091	2.448–3.902	<0.001	0.985	0.681–1.424	0.936
Clinical stage
I	1.000			1.000
II	3.742	2.213–6.325	<0.001	3.254	1.909–5.546	<0.001
III	5.267	3.239–8.563	<0.001	3.435	2.013–5.864	<0.001
IV	11.25	6.855–18.461	<0.001	5.685	3.063–10.549	<0.001
CRP-SAA
Low level	1.000			1.000
High level	2.097	1.673–2.628	<0.001	1.545	1.223–1.951	<0.001
Total SAA
Low level	1.000			1.000
High level	1.778	1.429–2.212	<0.001	1.329	1.061–1.663	0.013
CRP
Low level	1.000			1.000
High level	2.045	1.641–2.549	<0.001	1.454	1.156–1.829	0.001

“−”, age and sex are not included in the Multivariate Cox regression analysis. Other footnotes as in Table 4.