Table 4.
Relationship of some neurodegenerative and vascular measures with MMSE score, from 693 BBDP subjects
| Measurement | Mean (SD) | Correlation with MMSE | OR for lower MMSE |
|---|---|---|---|
| Age | 84.9 (6.7) | — | — |
| MMSE | 18.6 (9.5) | — | — |
| Neuritic plaque density | 2.1 (1.2) | −0.47 (P < 0.0001) | 1.3 (P = 0.002) |
| Braak stage | 4.1 (1.3) | −0.56 (P < 0.0001) | 2.1 (P < 0.0001) |
| Lewy type synucleinopathy brain summary score | 7.8 (11.2) | −0.18 (P < 0.0001) | 1.02 (P = 0.02) |
| White matter rarefaction score | 4.2 (3.4) | −0.19 (P < 0.0001) | 1.08 (P = 0.02) |
| Amyloid angiopathy score | 3.4 (3.5) | −0.31 (P < 0.0001) | 1.00 (P = 0.88) |
| Number of cortical microinfarcts | 0.84 (2.9) | −0.04 (P = 0.25) | 0.99 (P = 0.87) |
Correlations were performed with the Spearman method. Logistic regression analysis provided odds ratios (OR) for each factor’s association with a lower MMSE score (<24), corrected for the influence of all other factors. MMSE, Mini Mental State Examination.