Table 5.
Neuropathological diagnosis | n | % |
---|---|---|
Normal† | 238 | 20 |
Alzheimer’s disease | 665 | 57 |
Dementia with Lewy bodies | 107 | 9 |
Parkinson’s disease | 170 | 14 |
Vascular dementia | 110 | 9 |
Progressive supranuclear palsy | 80 | 6.8 |
Hippocampal sclerosis | 64 | 5 |
Dementia lacking distinctive histology | 13 | 1.1 |
Multiple system atrophy | 8 | 0.7 |
Frontotemporal lobar degeneration with TDP-43 | 18 | 1.5 |
Motor neuron disease | 12 | 1.0 |
Corticobasal degeneration | 8 | 0.7 |
Pick’s disease | 5 | 0.4 |
Neurofibrillary tangle predominant dementia | 5 | 0.4 |
Huntington’s disease | 2 | 0.2 |
Multiple major neurodegenerative diagnoses | 349 | 37 |
Earlier autopsies before 1997 did not receive a full neuropathological examination. As more than one condition is often present in a single subject, the sum of the percentages exceeds 100. The percentage of subjects with multiple major clinicopathological conditions excludes the normal subjects from the denominator. Subjects listed as “multiple major neurodegenerative diagnoses have more than one of the listed conditions below.
No major clinical neurological diagnosis.