Table 3.
Gray matter proton metabolite values and ratios from patients with Parkinson’s disease and controls.
| Brain Region | Group Means (SD)
|
% Difference from Control | |||
|---|---|---|---|---|---|
| PD (n = 12) | Control (n = 18) | ||||
| Frontal | Left | NAA | 2191(154) | 2259(132) | −3.0 |
| Cre | 1669(121) | 1736(113) | −3.9 | ||
| Cho | 370(37) | 372(52) | −0.7 | ||
| NAA/Cre | 1.32(.096) | 1.30(.070) | 1.2 | ||
| Cho/Cre | 0.22(.025) | 0.21(.025) | 4.6 | ||
| Cho/NAA | 0.17(.023) | 0.17(.021) | 2.9 | ||
| Right | NAA | 2179(164) | 2254(167) | −3.3 | |
| Cre | 1737(125) | 1773(156) | −2.0 | ||
| Cho | 369(32) | 381(55) | −3.2 | ||
| NAA/Cre | 1.25(.092) | 1.27(.076) | −1.1 | ||
| Cho/Cre | 0.21(.016) | 0.21(.025) | −1.2 | ||
| Cho/NAA | 0.17(.016) | 0.17(.019) | −0.0 | ||
| Parietal | Left | NAA | 2283(163) | 2353(199) | −3.0 |
| Cre | 1781(128) | 1797(146) | −0.9 | ||
| Cho | 285(38) | 277(38) | 2.9 | ||
| NAA/Cre | 1.27(.105) | 1.30(.068) | −2.2 | ||
| Cho/Cre | 0.15(.022) | 0.15(.017) | 5.0 | ||
| Cho/NAA | 0.13(.014) | 0.12(.013) | 7.0 | ||
| Right | NAA | 2420(180) | 2492(192) | −2.9 | |
| Cre | 1914(188) | 1881(164) | 1.8 | ||
| Cho | 281(45) | 289(42) | −2.9 | ||
| NAA/Cre | 1.25(.130) | 1.33(.075) | −6.0 | ||
| Cho/Cre | 0.13(.029) | 0.15(.018) | −8.2 | ||
| Cho/NAA | 0.12(.014) | 0.12(.014) | 1.0 | ||
| Temporal | Left | NAA | 2374(201) | 2450(233) | −3.1 |
| Cre | 1974(212) | 1896(206) | 4.1 | ||
| Cho | 338(54) | 358(63) | −5.6 | ||
| NAA/Cre | 1.13(.131)** | 1.27(.090) | −11.6 | ||
| Cho/Cre | 0.14(.028)** | 0.18(.032) | −18.9 | ||
| Cho/NAA | 0.14(.022) | 0.15(.027) | −3.7 | ||
| Right | NAA | 2746(213) | 2662(274) | 3.2 | |
| Cre | 2243(361)* | 1995(225) | 12.4 | ||
| Cho | 361(67) | 377(71) | −4.2 | ||
| NAA/Cre | 1.17(.213)* | 1.32(.121) | −11.5 | ||
| Cho/Cre | 0.13(.036)** | 0.18(.034) | −27.7 | ||
| Cho/NAA | 0.13(.032) | 0.14(.028) | −9.0 | ||
| Occipital | Left | NAA | 2223(266) | 2358(228) | −5.7 |
| Cre | 1874(276) | 1868(171) | 0.3 | ||
| Cho | 274(69) | 277(51) | −1.1 | ||
| NAA/Cre | 1.16(.156) | 1.25(.087) | −7.3 | ||
| Cho/Cre | 0.13(.025) | 0.14(.022) | −4.5 | ||
| Cho/NAA | 0.12(.021) | 0.12(.018) | 3.3 | ||
| Right | NAA | 2192(307)* | 2421(169) | −9.5 | |
| Cre | 1891(248) | 1852(115) | 2.1 | ||
| Cho | 259(71) | 255(43) | 1.8 | ||
| NAA/Cre | 1.14(.194)* | 1.30(.111) | −12.8 | ||
| Cho/Cre | 0.13(.029) | 0.13(.022) | −3.6 | ||
| Cho/NAA | 0.12(.029) | 0.11(.019) | 10.5 | ||
| Total Cerebrum | NAA | 2325(133) | 2406(151) | −3.3 | |
| Cre | 1885(144) | 1850(122) | 1.9 | ||
| Cho | 317(31) | 323(38) | −1.9 | ||
| NAA/Cre | 1.21(.110)* | 1.29(.054) | −6.4 | ||
| Cho/Cre | 0.16(.015) | 0.17(.016) | −6.8 | ||
| Cho/NAA | 0.14(.012) | 0.14(.014) | 1.0 | ||
Note. Metabolite values are in institutional units. Significant differences in metabolites levels between groups for white matter regions are provided in the Results section. % Difference = ((PD−Control)/Control)*100.
*
p ≤ .05
**
p ≤ .01