Figure 2.

Contribution of CD4+ T cell subsets to the HIV reservoir during ART. CD4+ T cell subsets can be classified according to their differentiation and memory status (top) or to their effector functions (bottom). Cell-surface markers and the production of specific cytokines can be used to identify each individual subset. The relative contribution of each subset to the HIV reservoir is indicated.

(Adapted from Geginat et al. Semin Immunol 2013; 25: 252–262; Geginat et al. Front Immunol 2014; 16 Dec 2014.)