Fig 2. Proteins encoded by multifunctional genes are longer, have more domains, and are more disordered.

Boxplots for length, number of unique domains, and fraction of disordered residues in proteins encoded by multifunctional and other annotated genes are shown for (A) fly, (B) human, and (C) yeast. Colored dots show the means, notches show bootstrap-generated 95% confidence intervals around the medians, boxes show quartile ranges, and whiskers extend to the most extreme data points within 1.5 times the size of the inner quartile range. For genes in fly and human, if a gene has more than one protein isoform, the longest isoform is considered. Multifunctional genes are significantly longer, have a significantly larger number of unique domains, and are significantly more disordered (Mann–Whitney U test).