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. 2015 Oct 5;11(10):e1004467. doi: 10.1371/journal.pcbi.1004467

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© 2015 Pritykin et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — Boxplots of evolutionary conservation (estimated by phastCons [32] for each nucleotide, averaged over the nucleotides of each gene) of multifunctional and other annotated genes are shown for (A) fly, (B) human, and (C) yeast. Colored dots show the means, notches show bootstrap-generated 95% confidence intervals around the medians, boxes show quartile ranges, and whiskers extend to the most extreme data points within 1.5 times the size of the inner quartile range. Multifunctional genes are significantly more evolutionary conserved than other annotated genes (Mann–Whitney U test).