Table 2. Sensitivity and specificity of clinical criteria for detecting patients with pathogenic mutations in four MMR genes (MLH1, MSH2, MSH6 and PMS2).

Clinical criteria	Families fulfilling criteria	Families positive for MMR mutations	Positive families missed by criteria	Sensitivity (95%CI)	Specificity (95%CI)
Amsterdam I and II	49	31	15	67% (52%-80%)	74% (62%-84%)
Bethesda	112	45	1	98% (88%-100%)	4% (1%-12%)

^{CI: Confidence interval}