Table I.
Stiffness of the cadherin surface | Cadherin (Cell type) | ref | |||||
---|---|---|---|---|---|---|---|
1 kPa | 8.5-9 kPa | 34 kPa | 95 kPa | 120 kPa | |||
Stress developed at cadherin adhesions | - | 150 pN/μm2 | 1300 pN/μm2 | 4 nN/μm2 | 4 nN/μm2 | N-cad (C2C12) | [22, 23] |
<10 pN/μm2 | - | 500 pN/μm2 | - | - | N-cad (MDA-MB-435) | [64] | |
43 pN/μm2 | - | 160 pN/μm2 | - | - | E-cad (MDCK, DLD) | [62] | |
<10 pN/μm2 | - | 550 pN/μm2 | - | - | E-cad (MDCK) | [64] | |
- | 100 pN/μm2 | - | - | - | E-cad (MDCK) | [63] |
Measurements have been obtained for cells spread on deformable cadherin-coated substrates of controlled stiffness, either micropillars [22, 23] or polyacrymamide gels [62-64]. As a matter of comparison, 1 kPa is equivalent to lung tissue stiffness [62], and stiffness of renal tissue ranges from 4.3 to 6.8 kPa from the cortex to the renal sinus [109].