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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Mol Cell Neurosci. 2015 Jun 16;68:177–185. doi: 10.1016/j.mcn.2015.06.008

Figure 1. Co-release of neuropeptides stimulated by secretagogues: basal and stimulated secretion.

Figure 1

Chromaffin cells were treated with (and without) the secretagogues of high KCl (50 mM), nicotine (10 μM), carbachol (1 mM), PACAP (0.1 μM), bradykinin (0.3 μM), and histamine (10 μM) for 15 minutes and the media was collected for measurements of Met-enkephalin, galanin, NPY, and VIP neuropeptides (panels A, B, C, and D, respectively). Graphs show plots of average secreted neuropeptide values among replicate cellular samples (x ± s.e.m., replicates of n=3). Secretagogue stimulation of released neuropeptides was compared to control (no secretagogue) conditions (*statistically significant, p < 0.05).