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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Curr Opin Immunol. 2015 Aug 5;36:101–108. doi: 10.1016/j.coi.2015.07.006

Figure 2.

Figure 2

miRNAs as endogenous regulators, novel biomarkers and potential therapeutic agents in allergic inflammation. (a) Genetic loss of function studies and administration of miRNA mimics/inhibitors demonstrate a significant role for the endogenous expression and exogenous manipulation of individual miRNAs in the regulation of mouse models of asthma. (b) Extracellular miRNAs are stable and present in body fluids within exosomes, bound to Argonaute and associated with lipoproteins. While their cellular sources and potential functions remain largely unknown, they have the potential to guide the development of novel biomarkers and therapies in diseases including allergy and asthma.