Figure 3.

Blocking intrinsic activity increases striatal CaMKII activity. Mouse brain slices were incubated for 30 min with tetrodotoxin (TTX; 1 μM; gray bars) or vehicle (white bars). Lysates of dorsal striatal punches were immunoblotted for P-Thr286 and total CaMKIIα. Representative blots are shown above the bar graph reporting the P-Thr286/total CaMKIIα ratio as the mean ± SEM for the indicated number of replicates. Significance determined by unpaired Student's t-test (*p<0.05).