Fig. 1.

Effects of total saponin from Korean Red Ginseng (KRG-TS) on thrombin-induced human platelet aggregation. (A) Concentration threshold of thrombin on human platelet aggregation. (B) Effects of KRG-TS on resting human platelets. (C) Effects of KRG-TS on thrombin-induced human platelet aggregation. (D) Half-maximal inhibitory concentration (IC₅₀) value of KRG-TS in thrombin-stimulated human platelet aggregation. Measurement of platelet aggregation was carried out as described in the “Materials and methods” section. The rate of inhibition by KRG-TS was recorded as the percentage of thrombin-induced aggregation rate. The IC₅₀ value of KRG-TS was calculated according to the four-parameter log-fit method. Data are expressed as the mean ± standard deviation (n = 4). *p < 0.05 versus the thrombin-induced human platelet aggregation.