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. 2015 Mar 28;39(4):354–364. doi: 10.1016/j.jgr.2015.03.006

Fig. 2.

Fig. 2

Effects of total saponin from Korean Red Ginseng (KRG-TS) on thrombin-induced human platelet aggregation in the presence of cyclic adenosine monophosphate-dependent protein kinase (PKA) or cyclic guanosine monophosphate-dependent protein kinase (PKG) inhibitor. (A) Effects of KRG-TS, PKA inhibitor, or PKG inhibitor on thrombin-elevated light transmission: (a) thrombin (0.05 U/mL); (b) thrombin (0.05 U/mL) + KRG-TS (150 μg/mL) + Rp-8-Br-cAMPS (250μM); (c) thrombin (0.05 U/mL) + KRG-TS (150 μg/mL) + Rp-8-Br-cGMPS (250μM); and (d) thrombin (0.05 U/mL) + KRG-TS (150 μg/mL). (B) Effects of KRG-TS, PKA inhibitor, or PKG inhibitor on thrombin-induced human platelet aggregation. Washed human platelets (108/mL) were preincubated with KRG-TS (150 μg/mL) in the presence of PKA inhibitor (Rp-8-Br-cAMPS) or PKG inhibitor (Rp-8-Br-cGMPS) for 3 min at 37°C, and then thrombin (0.05 U/mL) was added. Data are expressed as the mean ± standard deviation (n = 4). *p < 0.05 versus the thrombin-stimulated human platelets. **p < 0.05 versus the thrombin-stimulated platelets in the presence of KRG-TS (150 μg/mL).