Skip to main content
. 2015 Aug 20;119(7):817–823. doi: 10.1152/japplphysiol.00467.2015

Fig. 1.

Fig. 1.

Effect of hypertension and unilateral common carotid artery occlusion (UCCAo) on parenchymal arteriole (PA) myogenic activity. A: inner diameters vs. intravascular pressure of PAs from either 18-wk-old Wistar-Kyoto (WKY18) or 5- and 18-wk-old spontaneously hypertensive stroke prone (SHRSP5 and SHRSP18, respectively) rats that were naive, or from WKY18 and SHRSP18 rats that underwent 4 wk of UCCAo (WKY18-CH and SHRSP18-CH, respectively). PAs were taken from the ipsilateral side to occlusion. Both SHRSP5 and SHRSP18 animals had PAs with smaller lumen diameters compared with WKY18 at all pressures. These vessels displayed myogenic activity as diameter did not change with increased pressure. UCCAo caused increased diameters in PAs from WKY18-CH animals and diminished reactivity to pressure. There was little effect of UCCAo on PAs form SHRSP18-CH animals. B: percent myogenic tone of PAs from all groups of animals at 60 mmHg. Myogenic tone was increased in both SHRSP5 (SP5) and SHRSP18 (SP18) compared with WKY18 animals. UCCAo decreased tone only in WKY18-CH animals. Values are means ± SE; n, no. of rats. ^^P < 0.01 vs. WKY18. **P < 0.01 vs. all.