Fig. 2.
Effect of hypertension and UCCAo on PA reactivity to nitric oxide. A: constriction of PAs to nitric oxide synthase inhibition with Nω-nitro-l-arginine (l-NNA; 10−4 M). All vessels constricted to nitric oxide synthase inhibition that was less in SHRSP5 (SP5) and after UCCAo in WKY18-CH animals. ^P < 0.05 vs. WKY18. ^^P < 0.01 vs. WKY18. ##P < 0.01 vs. SP18. B: percent reactivity as a measure of dilation to sodium nitroprusside (SNP). All vessels dilated to SNP that was greater in PAs from SHRSP18, regardless of UCCAo, compared with age-matched WKY18 and SHRSP5 animals. The dilation curve to SNP could not be performed on PAs from WKY18-CH animals, as they were already dilated. ^P < 0.05 vs. SHRSP18 and SHRSP18-CH. **P < 0.01 vs. all. Values are means ± SE; n, no. of rats.