Table 1.
Comparison of clinical nonselective nonsteroidal anti-inflammatory drug doses with doses used in functional experiments
| Compound | Tablet/Capsule Concentration (Active), mg | 5% of Tablet/Capsule Concentration (Potential Renal Exposure During Excretion), mg | Concentration Used in Functional Experiments |
|---|---|---|---|
| Meloxicam | 7.5 | 0.38 | 2.45 mg (1 mM) |
| 15 | 0.75 | ||
| Indomethacin | 25 | 1.25 | 0.075 mg (30 μM) |
| 50 | 2.5 | ||
| Celecoxib | 50 | 2.5 | 0.81 mg (300 μM) |
| 100 | 5 | ||
| 50 | 10 | ||
| 400 | 20 |
Renal exposure to clinical nonselective nonsteroidal anti-inflammatory drug doses was extrapolated and compared with concentrations used in functional experiments.