Fig. 1.

Effect of electrogenic Na⁺-coupled bicarbonate (HCO₃⁻) cotransporter (NBCe1) deletion on serum electrolytes. Left: effects on serum HCO₃⁻. NBCe1 deletion induced a gene dose-dependent decrease in serum HCO₃⁻. n = 7, 7, and 6 for wild-type (Wt), heterozygous (Het), and homozygous NBCe1 deletion [knockout (KO)], respectively. Middle and right: effects on serum Na⁺ (middle) and K⁺ (right). NBCe1 deletion did not significantly alter either serum Na⁺ or K⁺. n = 5, 5, and 4 for wild-type, heterozygous, and homozygous NBCe1 deletion, respectively, for Na⁺ and n = 7, 7, and 5 for wild-type, heterozygous, and homozygous NBCe1 deletion, respectively, for K⁺.