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. 2015 Aug 6;309(7):G578–G589. doi: 10.1152/ajpgi.00189.2015

Fig. 2.

Fig. 2.

IGF1R loss does not alter measures of colon growth in lean or obese mice, and neither obesity nor IGF1R deletion impacts IR protein levels in CECs. A–C: colon weight, length, and crypt depth. Values are means ± SE (n = 6 WT-Lean, 4 WT-Obese, 5 VC-Lean, and 4 VC-Obese for colon weight and length; n = 7 WT-Lean, 6 WT-Obese, 6 VC-Lean, and 5 VC-Obese for crypt depth). D: representative Western blot showing IR protein in isolated CECs of lean and obese WT-IGF1Rfl/fl and VC-IGF1RΔ/Δ animals and quantification of IR protein levels relative to β-actin. Values are means ± SE (n = 3 WT-Lean, 4 WT-Obese, 3 VC-Lean, and 3 VC-Obese). aP < 0.05 vs. lean of the same genotype (by 2-way ANOVA with Tukey's multiple-comparisons test); ns, no significance.