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Summary of findings. After radiation-induced DNA damage in CECs, diet-induced obesity/hyperinsulinemia was associated with reduced apoptosis and reduced p53 and p53 targets (A), deletion of IGF1R did not impact apoptosis in lean or obese mice (B), and deletion of IR promoted increases in apoptosis in lean and obese animals, and this was associated with increased p53 and p53 targets (C).
