Table 1.
WT-IGF1Rfl/fl |
VC-IGF1RΔ/Δ |
WT-IRfl/fl |
VC-IRΔ/Δ |
|||||
---|---|---|---|---|---|---|---|---|
CTL | HFD | CTL | HFD | CTL | HFD | CTL | HFD | |
Body weight gain, % vs. start of diet | 39.5 ± 10.0 (6) | 101.6 ± 4.2a (9) | 31.2 ± 8.1 (5) | 93.9 ± 10.5a (7) | 24.9 ± 1.7 (8) | 70.4 ± 6.2a,b (9) | 25.7 ± 3.2 (7) | 71.0 ± 5.8a (12) |
Fasting blood glucose, mg/dl | 127.1 ± 11.3 (5) | 164.6 ± 16.4 (7) | 127.6 ± 17.3 (5) | 167.1 ± 13.8 (6) | 108.2 ± 2.3 (6) | 151.8 ± 11.3a (7) | 108.7 ± 8.8 (6) | 167.5 ± 10.4a (9) |
Fasting plasma insulin, μg/l | 0.2 ± 0.03 (5) | 1.1 ± 0.2a (7) | 0.3 ± 0.1 (5) | 1.3 ± 0.3a (6) | 0.27 ± 0.03 (6) | 1.16 ± 0.23a (7) | 0.27 ± 0.07 (6) | 1.14 ± 0.19a (9) |
HOMA | 2.3 ± 0.4 (5) | 13.9 ± 3.0a (7) | 2.5 ± 0.9 (5) | 15.0 ± 3.89a (6) | 2.0 ± 0.2 (6) | 12.6 ± 2.7a (7) | 2.2 ± 0.8 (6) | 15.4 ± 2.8a (9) |
Plasma IGF1, ng/ml | 31.8 ± 11.2 (3) | 46.7 ± 3.8 (6) | 40.8 ± 4.0 (3) | 37.1 ± 6.6 (5) | 49.3 ± 2.6 (5) | 52.2 ± 4.5 (5) | 49.7 ± 3.3 (5) | 51.2 ± 2.2 (5) |
Values are means ± SE of number of mice in parentheses. IEC, intestinal epithelial cell; IGF1R, insulin-like growth factor 1 (IGF1) receptor; IR, insulin receptor; HOMA, homeostatic model assessment; CTL, control diet; HFD, high-fat diet.
P < 0.05 vs. CTL of the same genotype (by 2-way ANOVA and Tukey's multiple-comparisons test).
P < 0.05 vs. HFD-fed WT-IGF1Rfl/fl (by Student's t-test).