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. 2015 Aug 6;309(7):G578–G589. doi: 10.1152/ajpgi.00189.2015

Table 1.

IEC-specific loss of IGF1R or IR does not affect obesity-associated changes in body weight, blood glucose, plasma insulin, and insulin sensitivity

WT-IGF1Rfl/fl
VC-IGF1RΔ/Δ
WT-IRfl/fl
VC-IRΔ/Δ
CTL HFD CTL HFD CTL HFD CTL HFD
Body weight gain, % vs. start of diet 39.5 ± 10.0 (6) 101.6 ± 4.2a (9) 31.2 ± 8.1 (5) 93.9 ± 10.5a (7) 24.9 ± 1.7 (8) 70.4 ± 6.2a,b (9) 25.7 ± 3.2 (7) 71.0 ± 5.8a (12)
Fasting blood glucose, mg/dl 127.1 ± 11.3 (5) 164.6 ± 16.4 (7) 127.6 ± 17.3 (5) 167.1 ± 13.8 (6) 108.2 ± 2.3 (6) 151.8 ± 11.3a (7) 108.7 ± 8.8 (6) 167.5 ± 10.4a (9)
Fasting plasma insulin, μg/l 0.2 ± 0.03 (5) 1.1 ± 0.2a (7) 0.3 ± 0.1 (5) 1.3 ± 0.3a (6) 0.27 ± 0.03 (6) 1.16 ± 0.23a (7) 0.27 ± 0.07 (6) 1.14 ± 0.19a (9)
HOMA 2.3 ± 0.4 (5) 13.9 ± 3.0a (7) 2.5 ± 0.9 (5) 15.0 ± 3.89a (6) 2.0 ± 0.2 (6) 12.6 ± 2.7a (7) 2.2 ± 0.8 (6) 15.4 ± 2.8a (9)
Plasma IGF1, ng/ml 31.8 ± 11.2 (3) 46.7 ± 3.8 (6) 40.8 ± 4.0 (3) 37.1 ± 6.6 (5) 49.3 ± 2.6 (5) 52.2 ± 4.5 (5) 49.7 ± 3.3 (5) 51.2 ± 2.2 (5)

Values are means ± SE of number of mice in parentheses. IEC, intestinal epithelial cell; IGF1R, insulin-like growth factor 1 (IGF1) receptor; IR, insulin receptor; HOMA, homeostatic model assessment; CTL, control diet; HFD, high-fat diet.

a

P < 0.05 vs. CTL of the same genotype (by 2-way ANOVA and Tukey's multiple-comparisons test).

b

P < 0.05 vs. HFD-fed WT-IGF1Rfl/fl (by Student's t-test).