Fig. 1.

1-[(2R,4S,5S)-4-55 azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione, azidothymidine (AZT)-induced gene expression changes. Wild-type mice (WT) were treated with AZT or vehicle (Veh) for 35 days (0.22 mg/day via gavage). RNA was isolated from left ventricle tissue, and cDNA was hybridized to an expression array. A: expression results from vehicle and AZT-treated WT mice. The Log₂ gene expression for each gene was plotted. B: Log₂ fold change and P value for gene expression results of AZT-treated WT mice to vehicle only. Green dots denote genes significantly overexpressed following AZT treatment; red dots denote genes significantly repressed following AZT.