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. 2015 Jul 28;47(10):500–513. doi: 10.1152/physiolgenomics.00057.2015

Fig. 1.

Fig. 1.

A: mouse embryonic fibroblast cells in which mutation of the NFAT5 gene inhibits its transcriptional activity (Null-MEFs) lack specific nuclear factor of activated T cells-5 (NFAT5) transcriptional activity. The MEFs were transfected with a luciferase reporter of NFAT5 transcriptional activity. Osmolality was increased from 300 to 500 mosmol/kg for 24 h in media bathing wild-type (WT-) or Null-MEFs or maintained at 300 or 500 mosmol/kg in media bathing adapted MEFs (#P < 0.05 vs. 300 mosmol/kg, *P < 0.05 vs. WT-MEFs). B–E: high NaCl regulates very few genes in common between WT- and Null-MEFs. B: number of genes upregulated after 24 h of high NaCl. C: number of genes downregulated after 24 h of high NaCl. D: number of genes that are upregulated in adapted MEFs. E: number of genes that are downregulated in adapted MEFs. F: number of genes upregulated in WT-MEFs and/or Null-MEFs.