Table 1.
IRF1 and NFAT5 binding sites are enriched at the promoter region (−10 to 2 kb around the transcription start site) of many up- and downregulated genes in WT- and Null-MEFs
| NFAT5 |
IRF1 |
|||
|---|---|---|---|---|
| WT-MEFs | Null-MEFs | WT-MEFs | Null-MEFs | |
| 24 h | ||||
| Upregulated | 1.86 (P = 0.059) | 0.66 | 2.09 (P = 0.09) | 0 |
| Downregulated | 0.89 | 1.28 | 2.90 (P = 0.006) | 0.49 |
| Adapted | ||||
| Upregulated | 2.48 (P = 0.003) | 1.40 | 3.10 (P = 0.03) | 2.00 |
| Downregulated | 0.68 | 0.80 | 3.24 (P = 0.002) | 0.62 |
IRF1, interferon regulatory factor 1; NFAT5, nuclear factor of activated T cells-5; MEF, mouse embryonic fibroblast cells; WT-MEF, wild-type MEF; Null-MEF, MEFs in which mutation of the NFAT5 gene inhibits its transcriptional activity.